Progressive Retinal Atrophy (PRA) is a category of genetic mutations that cause vision loss and blindness. Photoreceptor cells in the retina begin to degenerate, typically progressing from a loss of night vision to complete blindness.
PRA affects many different dog breeds, and these mutations are breed-specific. In Golden Retrievers, two mutations have been identified in addition to prcd-PRA known as GR-PRA1 and GR-PRA2.
Both GR-PRA1 and GR-PRA2 are inherited in an autosomal recessive manner. This means that a dog must inherit a copy of the mutation from each parent to be affected by the disorder. Dogs with one copy of the mutation will not show any signs or symptoms of PRA, however, they can still pass on that mutation to any offspring.